Abstract
The natural indole alkaloid (-)-tabersonine (1) easily provided (-)-decahydrotabersonine (4a), isolated as dihydrochloride (4b), by catalytic hydrogenation. Saponification of 4a led to the beta-amino acid 5. A binding study of 1, 4b, and 5 on various receptors and ionic channels showed that none of the compounds had a strong affinity for the receptors tested.
MeSH terms
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Alkaloids / chemical synthesis*
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Alkaloids / pharmacology*
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Animals
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Catalysis
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In Vitro Techniques
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Indole Alkaloids*
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Indoles*
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Kinetics
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Magnetic Resonance Spectroscopy
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Quinolines*
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Rats
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Receptors, Drug / drug effects*
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Spectrophotometry, Ultraviolet
Substances
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Alkaloids
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Indole Alkaloids
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Indoles
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Quinolines
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Receptors, Drug
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decahydrotabersonine
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tabersonine